AMCMRAdvances in Modern Chinese Medicine Research3068-06383068-0646Art and Design10.61369/AMCMR.202503011ArticleClinical Study on the Treatment of Erectile Dysfunction of Heart Gallbladder Qi Deficiency Type with Ethnic Medicine Huixin Grass Loadinghttps://artdesignp.com/journal/AMCMR/1/3/10.61369/AMCMR.202503011YuanShaoying,WangWen,LiangShulin,WangYoulian,QinZhan,GuanMingkun,NingWanjin,HeChaoba,GengLiguo2025132025-09-20Objective: To observe the therapeutic effect of traditional Chinese medicine (TCM) loaded with Western medicine on erectile dysfunction (heart and gallbladder “Qi” deficiency type), explore its clinical efficacy and safety, and provide new clinical ideas and methods for the application of TCM in the treatment of erectile dysfunction based on syndrome differentiation. Method: 80 patients who met the inclusion criteria for this clinical study and received treatment at the Men’s Outpatient Department of Zhuhai Hospital of Guangdong Provincial Hospital of Traditional Chinese Medicine from December 2023 to December 2024 were selected and divided into two groups using a random number table method, with 40 patients in each group. The control group received daily basic treatment medication: Tadalafil tablets, orally taken after lunch, 5 mg/time, once a day, for 8 weeks; The observation treatment group added 15g of Houttuynia cordata to the control group, which was decocted in water twice a day and taken orally in the morning and evening. The treatment course is 8 weeks, and the clinical efficacy of the two groups of  patients is objectively evaluated by observing the clinical efficacy rate (primary efficacy indicator), the efficacy rate of traditional Chinese medicine syndrome (secondary efficacy indicator), the improvement of international erectile function (IIEF-5) score, traditional Chinese medicine syndrome score, audio-visual stimulation erection test (AVSS), and erection  hardness (EHS) score before and after treatment. Result: The treatment group completed 40 cases, while the control group completed 39 cases. After treatment, the clinical effective rates of the observation group and the control group were 85.00% and 69.23%, respectively, and the difference between the observation group and the control group was statistically significant  (p < 0.05); The effective rates of traditional Chinese medicine syndrome in the observation group and the control group were 87.50% and 33.33%, respectively, and the difference between the observation group and the control group was statistically significant (p < 0.01); After treatment, the IIEF-5 scores of the observation group and the control group were 21.00 (19.25–23.75) and 18.00 (14.00–21.00) points, respectively. The difference between the observation group and the control group was statistically significant (p < 0.05); After treatment, the TCM syndrome scores of the observation group and the control group were 2.00 (2.00–6.00) points and 12.00 (6.00–20.00) points, respectively. The difference between the observation group and the control group was statistically significant (p < 0.01); After the treatment, the results of AVSS showed that the tip average rigidity of the observation group and the control group were 53.91 ± 11.98 and 47.63 ± 14.80, respectively, and the base average rigidity was 68.00 (53.75, 74.50) and 57.13 ± 9.38, respectively. The duration of tip erection was 11.53 ± 4.85 and 6.22 ± 1.93, respectively, and the duration of base erection was 11.28 ± 4.11 and 8.81 ± 3.50, respectively. The tip penile tumescence was 38.27 ± 6.48 and 33.44 ± 5.82, respectively, and the base penile tumescence was 38.64 ± 6.49 and 34.44 ± 5.80, respectively. The differences between the observation group and the control group were statistically significant (p < 0.005, p < 0.001); After treatment, the EHS scores of the observation group and the control group were 3.00 (3.00–4.00) points and 2.00 (2.00–3.00) points, respectively. The difference between the observation group and the control group was statistically significant (p < 0.05). Conclusion: Western medicine loaded with Huixincao can significantly improve the clinical efficacy of erectile dysfunction of heart and gallbladder “Qi” deficiency type, and can significantly improve ED and its associated clinical symptoms, improve patients’ traditional Chinese medicine symptoms, and have a good drug safety.Erectile dysfunction,Heart-gallbladder “Qi” deficiency,Huixincao,Tadalafil,Efficacy

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