<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2025030013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>天门冬— 红茶— 何首乌复合发酵液促进黑素生成的分子机制研究</title><url>https://artdesignp.com/journal/CDCST/2/3/10.61369/CDCST.2025030013</url><author>张燕梅,彭思彤,康丽,李颖妍,尹捷醇,韩娟娟,李燕龙,李柔柔,张太军</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>2</volume><issue>3</issue><history><date date-type="pub"><published-time>2025-09-25</published-time></date></history><abstract>头发的颜色由生长期毛囊内部合成的黑素决定，而黑素细胞的活性和功能受多种因素影响。由天门冬、红茶和何首乌经发酵得到的提取液可能具有促进黑素生成的功效，但其发挥作用的机制尚未明确。文章研究了天门冬、红茶和何首乌的复合发酵液促进黑素合成及其具体的分子机制。结果表明：浓度为1.25~5 mg/mL的该植物发酵液通过以下两种机制发挥作用：(i)通过调控Bcl-2/Bax-Caspase3信号通路抑制了H2O2诱导的B16细胞凋亡，显著提高细胞活性(p&amp;lt;0.001)；(ii) 通过TLR4/p38 MAPK信号通路激活黑素合成的功能。</abstract><keywords>植物发酵液,黑素,黑素瘤B16细胞,酪氨酸酶,信号通路</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Park AM, Khan S, Rawnsley J. 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