<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2025030014</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>藜麦发酵液的控油与舒缓功效研究</title><url>https://artdesignp.com/journal/CDCST/2/3/10.61369/CDCST.2025030014</url><author>陈登辉,邬佳颖,刘慢慢,张虹,沈义豪,黄虎,李响</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>2</volume><issue>3</issue><history><date date-type="pub"><published-time>2025-09-25</published-time></date></history><abstract>藜麦中富含多种类型的活性成分，但在化妆品行业中作为功效原料的应用开发还存在空间。为了探究藜麦的生物活性，开发了一种新型藜麦发酵液（FQE），并对其功效进行研究。生化实验表明，发酵后总酚含量增加了12.1%（p&amp;lt;0.05），FQE可显著降低TNF-&amp;alpha;水平，抑制率达到63.5%（p&amp;lt;0.01）；细胞实验表明FQE可显著抑制脂质积累，降低脂质过氧化物和炎症介质的水平（p&amp;lt;0.01）。此外，在连续使用藜麦发酵液2周后，志愿者皮肤皮脂量减少了17.2 &amp;mu;g/cm2。SLS斑贴刺激实验证明FQE可有效增加角质层水合度、显著降低经表皮水分流失和红斑指数（p&amp;lt;0.001）。本研究表明FQE具有有抗炎、舒缓和控油的功效，为油性皮肤的护理提供了新的选择。</abstract><keywords>藜麦发酵液,皮肤,控油,抗炎</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Maia Campos P M B G, Melo M O, Mercurio D G. Use of advanced imaging techniques for the characterization of oily skin[J]. Frontiers in Physiology, 2019, 10: 254.[2]Tang J, Diao P, Shu X, et al. Quercetin and quercitrin attenuates the inflammatory response and oxidative stress in LPS ‐induced RAW264.7 cells: In vitro assessment and a theoretical model[J]. BioMed research international, 2019(1): 7039802.[3]Sun Q, Hu S, Lou Z, et al. The macrophage polarization in inflammatory dermatosis and its potential drug candidates[J].Biomedicine &amp;amp; Pharmacotherapy, 2023, 161: 114469.[4]Angeli V, Miguel Silva P, Crispim Massuela D, et al. Quinoa (Chenopodium quinoa Willd.): An overview of the potentials of the &amp;ldquo;golden grain&amp;rdquo; and socio-economic and environmental aspects of its cultivation and marketization[J]. Foods, 2020, 9(2): 216.[5]Tang M, Zhang Q, Wang X, et al. Study on extraction, isolation, and biological activity of saponins from quinoa bran[D]. Journal of Food Processing and Preservation, 2022, 46(12): e17155.[6]Navruz-Varli S, Sanlier N. Nutritional and health benefits of quinoa (Chenopodium quinoa Willd.) [J]. Journal of cereal science, 2016, 69: 371-376.[7]杨洁,高凤祥,杨敏, 等. 藜麦皮总皂苷微波辅助提取工艺及其抗氧化活性研究 [J]. 食品与机械, 2017, 33(12): 148-153, 185.[8]刘兴浩,崔亚君,王佳凯, 等. 藜麦营养功能特性及其在植物基食品中的应用 [J/OL]. 中国粮油学报, 1-11[2025-06-20].[9]李萍,罗强,金鑫, 等. 藜麦皂苷的提取及其酪氨酸酶抑制活性[J]. 现代食品科技, 2021, 37 (05): 196-202,129.[10]何海芬,朱统臣,林飞武. 藜麦在化妆品中的应用前景 [J]. 广东化工, 2018, 45 (02): 120-122,134.[11]Han C, Lin B, Huang X, et al. Quinoa husk peptides reduce melanin content via Akt signaling and apoptosis pathways[J]. Iscience, 2023,26(1).[12]国家市场监督管理总局, 中国国家标准化管理委员会.茶叶中茶多酚和儿茶素类含量的检测方法: GB/T 8313-2018[S].北京: 中国标准出版社, 2018.[13]Song Y J, Bao J M, Zhang Z Q, et al. Arctiin protects chondrocytes from interleukin-1&amp;beta;-induced inflammation and apoptosis by RNA sequence in vivo and in vitro[J]. World Journal of Traditional Chinese Medicine, 2024, 10(4): 495-511.[14]鞠强,夏隆庆,尹兴平, 等. 盐酸小檗碱、黄芩苷和苦参碱对SZ95皮脂腺细胞增殖及脂质合成的影响 [J]. 中华皮肤科杂志,2005, (11): 662-664.[15]袁道欢,黄嘉敏,林霁, 等. 青蒿提取物舒缓与控油祛痘功效研究 [J]. 日用化学品科学, 2024, 47 (08): 42-46.[16]卢伊娜,王光寅,谢红, 等. 三皮素对抗痤疮的功效研究 [J]. 日用化学工业, 2019, 49 (01): 29-33.[17]卢伊娜,杨雅迪,谢智勇, 等. 墨藻胶对皮肤水合及屏障功能的促进作用研究 [J]. 日用化学工业, 2017, 47 (12): 709-712.[18]Hoang H T, Moon J Y, Lee Y C. Natural antioxidants from plant extracts in skincare cosmetics: Recent applications, challenges and perspectives[J]. Cosmetics, 2021, 8(4): 106.[19]Repo-Carrasco-Valencia R, Hellstr&amp;ouml;m J K, Pihlava J M, et al. Flavonoids and other phenolic compounds in Andean indigenous grains: Quinoa (Chenopodium quinoa), ka&amp;ntilde;iwa (Chenopodium pallidicaule)and kiwicha (Amaranthus caudatus) [J]. Food chemistry, 2010, 120(1):128-133.[20]Kim J E, Han H, Xu Y, et al. Efficacy of FRO on acne vulgaris pathogenesis[J]. Pharmaceutics, 2023, 15(7): 1885.[21]Inoue T, Miki Y, Kakuo S, et al. Expression of steroidogenic enzymes in human sebaceous glands[J]. J Endocrinol, 2014, 222(3): 301-312.[22]侯凤艳,罗莉,朱俊宇, 等. 胍丁胺对脂多糖诱导RAW264.7细胞氧化应激损伤的保护作用 [J]. 第三军医大学学报, 2016, 38 (09):949-953.[23]Valko M, Leibfritz D, Moncol J, et al. Free radicals and antioxidants in normal physiological functions and human disease[J].The international journal of biochemistry &amp;amp; cell biology, 2007, 39(1): 44-84.[24]Sung M, Lim S, Park S, et al. Anti-inflammatory effects of phytosphingosine-regulated cytokines and NF-kB and MAPKmechanism[J]. Cellular and Molecular Biology, 2024, 70(9): 22-30.[25]Sangiovanni E, Di Lorenzo C, Piazza S, et al. Vitis vinifera L. leaf extract inhibits in vitro mediators of inflammation and oxidative stress involved in inflammatory-based skin diseases[J]. Antioxidants, 2019,8(5): 134.[26]张荣,李晓歌,陈雁斌, 等. Rab18通过PPAR&amp;gamma;下调PLIN2以减少巨噬细胞脂质蓄积 [J]. 中国病理生理杂志, 2021, 37 (08): 1367-1375.[27]Gu H, An H J, Gwon M G, et al. The effects of synthetic srebp-1 and ppar-&amp;gamma; decoy oligodeoxynucleotide on acne-like disease in vivo and in vitro via lipogenic regulation[J]. Biomolecules, 2022, 12(12):1858.[28]Najt C P, Lwande J S, McIntosh A L, et al. Structural and functional assessment of perilipin 2 lipid binding domain (s)[J]. Biochemistry,2014, 53(45): 7051-7066.[29]Libby A E, Bales E, Orlicky D J, et al. Perilipin-2 deletion impairs hepatic lipid accumulation by interfering with sterol regulatory element-binding protein (SREBP) activation and altering the hepatic lipidome[J]. Journal of Biological Chemistry, 2016, 291(46): 24231-24246.[30]Rosignoli C, Nicolas J C, Jomard A, et al. Involvement of the SREBP pathway in the mode of action of androgens in sebaceous glands in vivo[J]. Experimental dermatology, 2003, 12(4): 480-489.[31]Flowers M T, Paton C M, O&amp;rsquo;Byrne S M, et al. Metabolic changes in skin caused by Scd1 deficiency: a focus on retinol metabolism[J]. PloS one, 2011, 6(5): e19734.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
