<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2025030015</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>神经酰胺脂质体和乳酸菌发酵溶胞产物协同抗
皮肤敏感分子机制的预测及验证研究</title><url>https://artdesignp.com/journal/CDCST/2/3/10.61369/CDCST.2025030015</url><author>刘昌杰,龚雪</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>2</volume><issue>3</issue><history><date date-type="pub"><published-time>2025-09-25</published-time></date></history><abstract>研究整合网络药理学与体外实验，探究神经酰胺脂质体与乳酸菌发酵溶胞产物协同改善皮肤敏感的作用机制。通过PubChem、PharmMapper 及GeneCards数据库获取靶点， 经Jvenn 分析确定340个交集靶点（ 核心为SRC、MAPK1、PIK3R1）， 并开展PPI网络、GO/KEGG富集分析。体外实验表明，神经酰胺脂质体与乳酸菌发酵溶胞产物联用可调控HaCaT细胞中SRC、MAPK1和AKT1的mRNA表达， 显著增强紧密连接蛋白（Occludin、Claudin-1 和Claudin-4）表达，同时抑制p-PI3K/AKT通路激活。该研究首次揭示二者协同抗皮肤敏感的分子机制，为皮肤屏障修复策略开发提供依据。</abstract><keywords>皮肤敏感,神经酰胺,乳酸菌发酵溶胞产物,网络药理学,实验验证</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]何黎. 中国敏感性皮肤临床诊疗指南(2024 版) [J]. 中国皮肤性病学杂志, 2024(05): 473-81.[2]RICHTERS R J, UZUNBAJAKAVA N E, HENDRIKS J C, et al. A model for perception-based identification of sensitive skin [J]. J Eur Acad Dermatol Venereol, 2017(2): 267-73.[3]MORIZOT F, GUINOT C, LOPEZ S, et al. Sensitive skin : Analysis of symptoms, perceived causes and possible mechanisms [J]. Cosmetics and toiletries, 2000(115): 83-89.[4]何黎, 郑捷, 马慧群, 等. 中国敏感性皮肤诊治专家共识[J]. 中国皮肤性病学杂志, 2017(01): 1-4.[5]HAUSMANN C, HERTZ-KLEPTOW D, ZOSCHKE C, et al. Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans [J]. Skin Pharmacol Physiol,2019(2): 72-80.[6]CUI H, FENG C, ZHANG T, et al. Effects of a lotion containing probiotic ferment lysate as the main functional ingredient on enhancing skin barrier: a randomized, self-control study [J]. Sci Rep, 2023(1): 16879.[7]CODERCH L, LOPEZ O, DE LA MAZA A, et al. Ceramides and skin function [J]. Am J Clin Dermatol, 2003(2): 107-29.[8]UCHIDA Y, PARK K. Ceramides in Skin Health and Disease: An Update[J]. Am J Clin Dermatol, 2021(6): 853-66.[9]FRANKE T F. PI3K/Akt: getting it right matters [J]. Oncogene, 2008(50): 6473-88.[10] 邢潇匀, 马蕾. PI3K/AKT 信号通路在银屑病发病机制中的研究进展[J]. 国际医药卫生导报, 2022(05): 594-7.[11] 王昊, 冉立伟, 惠珂, 等. Survivin和PI3K、AKT 在寻常型银屑病皮损角质形成细胞中的表达及其相关性 [J]. 南方医科大学学报,2017(11): 1512-6.[12]JEON Y J, KIM B H, KIM S, et al. Rhododendrin ameliorates skin inflammation through inhibition of NF-kappaB, MAPK, and PI3K/Akt signaling[J]. Eur J Pharmacol, 2013(1-3): 7-14.[13]ZHANG M, ZHANG X. The role of PI3K/AKT/FOXO signaling in psoriasis[J]. Arch Dermatol Res, 2019(2): 83-91.[14]WU X, YANG L, ZHENG Z, et al. Src promotes cutaneous wound healing by regulating MMP-2 through the ERK pathway [J]. Int J Mol Med, 2016(3): 639-48.[15]THRASH B R, MENGES C W, PIERCE R H, et al. AKT1 provides an essential survival signal required for differentiation and stratification of primary human keratinocytes [J]. J Biol Chem, 2006(17): 12155-62.[16]CHENG W, SHI X, ZHANG J, et al. Role of PI3K-AKT Pathway in Ultraviolet Ray and Hydrogen Peroxide-Induced Oxidative Damage and Its Repair by Grain Ferments [J]. Foods, 2023(4): 806.[17] 樊琳娜, 贾焱, 蒋丽刚, 等. 敏感皮肤成因解析及化妆品抗敏活性评价进展[J]. 日用化学工业, 2015(07): 409-14.[18]兰宇贞, 谢志强. 敏感性皮肤研究进展[J]. 中国中西医结合皮肤性病学杂志, 2013(03): 199-201.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
