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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2025030019</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>虾青素脂质体的制备研究进展</title><url>https://artdesignp.com/journal/CDCST/2/3/10.61369/CDCST.2025030019</url><author>丁翔,余述燕</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>2</volume><issue>3</issue><history><date date-type="pub"><published-time>2025-09-25</published-time></date></history><abstract>虾青素因其显著的抗氧化、抗炎以及免疫调节功能而备受关注。然而，其固有的低水溶性和由此导致的生物利用度受限制约了广泛应用。近年来，基于磷脂双分子层的脂质体递送系统，因其可有效包载疏水性药物、提高胃肠道稳定性及促进细胞摄取的特性，已成为改善虾青素递送效率的重要策略。文章系统地综述了虾青素脂质体的研究进展，重点关注制备技术与载体设计的优化，并对相关领域的应用前景进行了展望，旨在为基于虾青素纳米制剂的研发提供理论依据和技术参考。</abstract><keywords>虾青素,脂质体,包封率,工艺优化</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Li R, Chen R, Liu W, et al. Preparation of enteric-coated microcapsules of astaxanthin oleoresin by complex coacervation[J].Pharmaceutical Development and Technology, 2018, 23(7): 674-681.[2]Chen Z, Shu G, Taarji N, et al. Gypenosides as natural emulsifiers for oil-in-water nanoemulsions loaded with astaxanthin: Insights of formulation, stability and release properties[J]. Food Chemistry, 2018,261: 322-328.[3]Hama S, Takahashi K, Inai Y, et al. Protective effects of topical application of a poorly soluble antioxidant astaxanthin liposomal formulation on ultraviolet-induced skin damage[J]. Journal of Pharmaceutical Sciences, 2012, 101(8): 2909-2916.[4]Cardounel A J, Dumitrescu C, Zweier J L, et al. Direct superoxide anion scavenging by a disodium disuccinate astaxanthin derivative: Relative efficacy of individual stereoisomers versus the statistical mixture of stereoisomers by electron paramagnetic resonance imaging[J]. Biochemical and Biophysical Research Communications,2003, 307(3): 704-712.[5]Barros M P, Pinto E, Colepicolo P, et al. Astaxanthin and peridinin inhibit oxidative damage in Fe2+-loaded liposomes: Scavenging oxyradicals or changing membrane permeability?[J]. Biochemical and Biophysical Research Communications, 2001, 288(1): 225-232.[6]冯娇燕. 虾青素脂质体的制备及其特性研究[D]. 南京: 南京理工大学, 2022[7]Mart&amp;iacute;nez-&amp;Aacute;lvarez &amp;Oacute;, Calvo M M, G&amp;oacute;mez-Estaca J. Recent advances in astaxanthin micro/nanoencapsulation to improve its stability and functionality as a food ingredient[J]. Marine Drugs, 2020,18(8): 406.[8]黄文哲. 以纯胶为主要壁材微胶囊化虾青素的研究[D]. 无锡:江南大学, 2011.[9]Kim S. &amp;beta;-CD-mediated encapsulation enhanced stability and solubility of astaxanthin[J]. Journal of the Korean Society for Applied Biological Chemistry, 2010, 53(5): 559-565.[10] 李学艳, 王君文, 易金玉, 等. 含虾青素的雨生红球藻粉自微乳的制备及体外评价[J]. 上海海洋大学学报, 2021, 30(5): 940-949.[11]Ishikawa M, Hirai S, Yoshida T, et al. Carotenoid stereochemistry affects antioxidative activity of liposomes co-encapsulating astaxanthin and tocotrienol[J]. Chemical &amp;amp; Pharmaceutical Bulletin, 2018, 66(7): 714-720.[12]Ding L, Yang J, Yin K, et al. The spatial arrangement of astaxanthin in bilayers greatly influenced the structural stability of DPPC liposomes[J]. Colloids and Surfaces, B: Biointerfaces, 2022, 212,112383.[13]Dopierała K, Karwowska K, Petelska A D, et al. Thermodynamic,viscoelastic and electrical properties of lipid membranes in the presence of astaxanthin[J]. Biophysical Chemistry, 2020, 258: 106318.[14]Mercke Odeberg J, Lignell &amp;Aring;, Pettersson A, et al. Oral bioavailability of the antioxidant astaxanthin in humans is enhancedby incorporation of lipid based formulations[J]. European Journal of Pharmaceutical Sciences, 2003, 19(4): 299-304.[15]Shimokawa T, Yoshida M, Fukuta T, et al. Efficacy of high-affinity liposomal astaxanthin on up-regulation of age-related markers induced by oxidative stress in human corneal epithelial cells[J]. Journal Of Clinical Biochemistry And Nutrition, 2019, 64(1): 27-35.
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