[1]李利, 何黎, 刘玮. 护肤品皮肤科应用指南[J]. 中国皮肤性病学杂志,2015, 29(6):553-555.[2]何黎, 刘玮, 李利. 舒敏保湿类护肤品在敏感性皮肤中的应用指南[J]. 中国皮肤性病学杂志, 2019, 33(11):1229-1231.[3] 何黎. 祛斑美白类护肤品在黄褐斑中的应用指南[J]. 中国皮肤性病学杂志, 2022, 36(2):123-127.[4]Robson K.J, Stewart M.E, Michelsen S, et al, 6-Hydroxy-4sphingenine in human epidermal ceramides[J]. J. Lipid Res. 1994, 35:2060-2068.[5]Motta S, Monti M, Sesana S, et al, Ceramide composition of the psoriatic scale, Biochim. Biophys. Acta[J]. 1993, 1182: 147-151.[6]Breiden B, Sandhoff K, The role of sphingolipid metabolism in cutaneous permeability barrier formation[J], Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2014, 1841(3):441-452.[7]Masukawa Y Y, Narita H H, Shimizu E E, et al. Characterization of overall ceramide species in human stratum corneum [J]. Journal of Lipid Research, 2008, 49 (7):1466.[8]T’Kindt R, Jorge L, Dumont E, et al, Profiling and characterizing skin ceramides using reversed-phase liquid chromatographyquadrupole time-of-flight mass spectrometry [J]. Analytical Chemistry, 2012, 84 (1) :403-411.[9]Wertz P W, Lipids and barrier function of the skin[J]. Acta Derm Venereol Suppl (Stockh), 2000, 208: 7-11. [10]Lee J B, Sung M, Noh M, et al, Effective association of ceramidecoassembled lipid nanovehicles with stratum corneum for improved skin barrier function and enhanced skin penetration[J]. Int J Pharm, 2020, 579: 119162.[11]Bouwstra J A, Gooris G S, Dubbelaar F E, et al, Role of ceramide 1 in the molecular organization of the stratum corneum lipids[J]. J Lipid Res, 1998, 39: 186-196.[12]Che H J, He C F, Zhao H, et al, Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)[J], 2016,38: 16-22[13]赖彦云,陶思睿,杨莉, 等.含神经酰胺的保湿剂改善皮肤干燥的功效和安全性研究[J]. 中国美容医学, 2022, 31(2): 62-66.[14]Kahraman E, Kaykın M, Şahin Bektay H, Güngör S. Recent Advances on Topical Application of Ceramides to Restore Barrier Function of Skin[J]. Cosmetics. 2019, 6(3):52.[15]王贺聪, 何聪芬.皮肤中神经酰胺的研究及应用现状[J]. 日用化学工业, 2019, 49(1): 51-57.[16]Meckfessel, M.H.; Brandt, S. The structure, function, and importance of ceramides in skin and their use as therapeutic agents in skin-care products[J]. J. Am. Acad. Dermatol. 2014, 71, 177-184.[17]Jensen JM, Förl M, Winoto-Morbach S, Seite S, Schunck M, Proksch E and Schütze S: Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging[J]. Exp Dermatol 2005, 14: 609-618.[18]Jensen J M, Fölster-Holst R, Baranowsky A, Schunck M, Winoto-Morbach S, Neumann C, Schütze S and Proksch E: Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis[J]. J Invest Dermatol 2004, 122: 1423-1431 .[19]Ponnusamy, S., Meyers-Needham, M., Senkal, C. E, et al. Sphingolipids and Cancer: Ceramide and Sphingosine-1-Phosphate in the Regulation of Cell Death and Drug Resistance[J]. Future Oncology, 2010, 6(10): 1603–1624.[20]Ponnusamy S, Meyers-Needham M, Senkal C E, Sphingolipids and cancer: ceramide and sphingosine-1-phosphate in the regulation of cell death and drug resistance[J]. Future Oncol, 2010, 6: 1603-1624.[21]Cha H J, He, C F. Intercellular and intracellular functions of ceramides and their metabolites in skin (Review)[J]. International Journal of Molecular Medicine, 2016, 38: 16-22,[22]刘韵祎, 神经酰胺与相关皮肤病的研究进展[J]. 中国麻风皮肤病杂志, 2020, 36 (10): 626-630.[23]Cui L, Jia Y, Cheng ZW, et al. Advancements in the maintenance of skin barrier/skin lipid composition and the involvement of metabolic enzymes[J]. J Cosm Dermatol, 2016, 15( 4) : 549-558．[24]魏静, 张伟敏, 钟耕, 神经酞胺对皮肤生理作用及其在化妆品中应用[J]. 粮食与油脂, 2007, 1:21-24.[25]黄韬，乔小玲, 神经酰胺的研究进展及在护肤品中的应用[J].上海师范大学学报( 自然科学版), 2023, 52 (6):723-735.[26]刘媛, 神经酰胺代谢途径对皮肤屏障功能影响研究进展[J]. 中国麻风皮肤病杂志, 2017, 33(1): 619-623.[27]Shin J, Kim YJ, Kwon O, et al. Associations among plasma vitamin C, epidermal ceramide and clinical severity of atopic dermatitis[J]. Nut Res Pract, 2016, 10(4) : 398-403．[28]Liu M, Li X, Chen XY，et al. Topical application of a linoleic acid-ceramide containing moisturizer exhibit therapeutic and preventive benefits for psoriasis vulgaris: a randomized controlled trial[J]. Dermatol Therapy，2015，28(6) : 373- 382.[29]A. N. Fasseeh, B. Elezbawy, N. Korra, et al. Burden of Atopic Dermatitis in Adults and Adolescents: A Systematic Literature Review[J], Dermatology and Therapy, 2022,12 (12): 2653-2668,[30]Pappas, A.; Kendall, A.C.; Brownbridge, L.C. Batchvarova, N. Nicolaou, A. Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients[J]. Exp. Dermatol, 2018, 27,833-836.[31]Pilgram, G.; Van Der Meulen, J. Gooris, G. Koerten, H.; Bouwstra, J. The influence of two azones and sebaceous lipids on the lateral organization of lipids isolated from human stratum corneum[J]. Biochim. Biophys. Acta BBA Biomembr, 2001, 1511, 244-254.[32]Pilgram, G.S.; Vissers, D.C. Van Der Meulen, H.; Koerten, H.K. Pavel, S.; Lavrijsen, S.P.; Bouwstra, J.A. Aberrant Lipid Organization in Stratum Corneum of Patients with Atopic Dermatitis and Lamellar Ichthyosis[J]. J. Investig. Dermatol, 2001, 117, 710-717.[33]Macheleidt O, Kaiser H W, Sandhoff K. Deficiency of epidermal proteinbound omega-hydroxyceramides in atopic dermatitis[J]. J Invest Dermatol, 2002, 119(1): 166-173.[34]Janssens M, van Smeden J, Gooris GS, et al. Lamellar lipid organization and ceramide composition in the stratum eorneum of patients with atopic eczema [J]. J Invest Dermatol, 2011, 131(10) : 2136-2148．[35]Ishikawa J, Narita H, Kondo N, et al. Changes in the ceramide profile of atopic dermatitis patients[J]. J Invest Dermatol, 2010, 130 (10) : 2511-2514．[36]申春平, 贾志鑫. 神经酰胺在特应性皮炎皮肤屏障功能中的研究进展[J]. 皮肤科学通报, 2017, 34(4): 392-397.[37]Sawada E, Yoshida N, Sugiura A, Imokawa G. Th1 cytokines accentuate but Th2 cytokines attenuate ceramide production in the stratum corneum of human epidermal equivalents: an implication for the disrupted barrier mechanism in atopic dermatitis[J]. J Dermatol Sci. 2012, 68(1):25-35.[38]Kim J, Kim B E, Goleva E, et al, Alterations of Epidermal Lipid Profiles and Skin Microbiome in Children With Atopic Dermatitis[J], Allergy, Asthma & Immunology Research. 2023, 2 (15): 186-200.[39]Nugroho W T, Sawitri S, Astindari A, et al. The Efficacy of Moisturisers Containing Ceramide Compared With Other Moisturisers in the Management of Atopic Dermatitis, A Systematic LiteratureReview and Meta-Analysis[J], Indian Journal of Dermatology, 2023, 68, (1): 53-58.[40]Spada F, Harrison I P, Barnes T M, et al, A Daily Regimen of a Ceramide-Dominant Moisturizing Cream and Cleanser Restoresthe Skin Permeability Barrier in Adults With Moderate Eczema: A Randomized Trial[J], Dermatologic Therapy, 2021, 34(4): e14970.[41]Lynde C W, Andriessen A, A Cohort Study on a Ceramide- Containing Cleanser and Moisturizer Used for Atopic Dermatitis[J], Cutis; Cutaneous Medicine for the Practitioner, 2014, 93 (4): 207-213.[42]Koppes S A, Charles F, Lammers L, et al, Efficacy of a Cream Containing Ceramides and Magnesium in the Treatment of Mild to Moderate Atopic Dermatitis: A Randomized, Double-Blind, Emollientand Hydrocortisone-Controlled Trial[J], Acta Dermato-Venereologica, 2016, 96(7): 948-953.[43]Yang Q, Liu M, Li X, et al, The Benefit of a Ceramide Linoleic Acid-Containing Moisturizer as an Adjunctive Therapy for a Set of Xerotic Dermatoses[J], Dermatologic Therapy, 2019, 32(4): e13017[44]Ma L, Li P, Tang J, et al, Prolonging Time to Flare in Pediatric Atopic Dermatitis: A Randomized, Investigator-Blinded, Controlled, Multicenter Clinical Study of a Ceramide-Containing Moisturizer[J], Advances in Therapy, 2017, 34(12): 2601-2611.[45]Ng P S M, Wee L W Y, Ho V P Y, et al, Moisturisers From Birth in At-Risk Infants of Atopic Dermatitis - a Pragmatic Randomised Controlled Trial[J], Australasian Journal of Dermatology, 2021, 62 (4): e539-e545.[46]Frankel A, Sohn A, Patel R V, et al, Bilateral Comparison Study of Pimecrolimus Cream 1% and a CeramideHyaluronic Acid Emollient Foam in the Treatment of Patients With Atopic Dermatitis[J], Journal of Drugs in Dermatology, 2011, 10(6): 666-672.[47]Weigle N, McBane S. Psoriasis. [J]. Am Fam Physician ,2013, 87(9) : 626 - 633．[48]Motta S, Monti M, Sesana S, et al. Ceramide composition of the psoriatic scale[J]. Biochim Biophys Acta. 1993, 1182: 147-51.[49]Yokose U, Ishikawa J, Morokuma Y, et al The ceramide [NP]/[NS] ratio in the stratum corneum is a potential marker for skin properties and epidermal differentiation[J]. BMC Dermatol. 2020, 20: 6.[50]Nakajima K, Terao M, Kataoka S, et al, Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model[J]. J Invest Dermatol，2013, 133 (11): 2555-2565．[51]Tawada C，Kanoh H，Nakamura M, et al, Interferon － γ decreases ceramides with long-chain fatty acids: possible involvement in atopic dermatitis and psoriasis[J]. J Invest Dermatol, 2014, 134(3) : 712-718．[52]Hile G A, Gudjonsson J E, Kahlenberg J M. The influence of interferon on healthy and diseased skin[J]. Cytokine, 2020,132:154605.[53]Del Rosso J Q, Ceramide- and Keratolytic-Containing Body Cleanser and Cream Application in Patients With Psoriasis: Outcomes From a Consumer Usage Study[J], Journal of Clinical and Aesthetic Dermatology, 2019, 12, (7): 18-21.[54]Liu M, Li X., Chen X Y, et al, Zheng, Topical Application of a Linoleic Acid-Ceramide Containing Moisturizer Exhibit Therapeutic and Preventive Benefits for Psoriasis Vulgaris: A Randomized Controlled Trial[J], Dermatologic Therapy, 2015, 28, (6): 373–382.[55]Li X, Yang Q, Zheng J, et al, Efficacy and Safety of a Topical Moisturizer Containing Linoleic Acid and Ceramide for Mild- ToModerate Psoriasis Vulgaris: A Multicenter Randomized Controlled Trial[J], Dermatologic Therapy, 2020, 33(6): e14263.[56]Man M Q, Ye L, Hu L, et al, Improvements in Epidermal Function Prevent Relapse of Psoriasis: A Self-Controlled Study[J], Clinical and Experimental Dermatology, 2019, 44, (6): 654–657.[57]Bhate K, Williams HC. Epidemiology of acne vulgaris[J]. Br J Dermatol. 2013, 168: 474-485.[58]Tan J, Beissert S, Cook-Bolden F, et al, Evaluation of psychological wellbeing and social impact of combined facial andtruncal acne: a multi-national, mixed-methods study[J]. Dermatol Ther (Heidelb). 2022, 12(8): 1847-1858.[59]Pappas A，Kendall A C，Brownbridge L C，et al． Seasonal changes in epidermal ceramides are linked to impaired barrier function in acne patients [J]. Exp Dermatol, 2018, 27 (8) : 833-836．[60]Kahraman E, Kaykın M, Şahin Bektay H, Güngör S. Recent Advances on Topical Application of Ceramides to Restore BarrierFunction of Skin[J]. Cosmetics. 2019, 6(3): 52.[61]Schachner L A, Alexis A F, Andriessen A, et al, Insights Into Acne and the Skin Barrier: Optimizing Treatment Regimens With Ceramide- Containing Skincare[J]. Journal of Cosmetic Dermatology, 2023, 22(11): 2902–2909.[62]Isoda K，Seki T，Inoue Y，et al． Efficacy of the combine use of a facial cleanser and moisturizers for the care of mild acne patients with sensitive skin[J]. J Dermatol，2015, 42 (2) : 181-188．[63]Del Rosso J Q，Brandt S． The role of skin care as an integral component in the management of acne vulgaris: part 2: tolerability and performance of a designated skin care regimen using a foam wash and moisturizer SPF 30 in patients with acne vulgaris undergoing active treatment[J]. J Clin Aesthet Dermatol, 2013, 6(12) : 28-36．[64] Karim N, Durbin-Johnson B , Rocke DM , et al.Proteomicmanifestations of genetic defects in autosomal recessive congenital ichthyosis[J]. J Proteomics, 2019, 201: 104-109.[65]Akiyama M. The roles of ABCA12 in keratinocyte differentiation and lipid barrier formation in the epidermis[J]. Dermatoendocrinol. 2011, 3(2):107–12.[66] Akiyama M. Corneocyte lipid envelope (CLE), the key structure for skin barrier function and ichthyosis pathogenesis[J]. J Dermatol Sci, 2017, 88(1) : 3-9．[67]Akiyama M, Sugiyama-Nakagiri Y, Sakai K, McMillan JR, GotoM, Arita K, et al. Mutations in lipid transporter ABCA12 in harlequin ichthyosis and functional recovery by corrective gene transfer[J]. J Clin Invest. 2005, 115(7): 1777-1784.[68]Lavrijsen AP, Bouwstra JA, Gooris GS, Weerheim A, Boddé HE, Ponec M. Reduced skin barrier function parallels abnormal stratum corneum lipid organization in patients with lamellar ichthyosis[J]. J Invest Dermatol. 1995, 105(4):619-24.[69]Paige DG, Morse-Fisher N, Harper JI. Quantification of stratum corneum ceramides and lipid envelope ceramides in the hereditary ichthyoses[J]. Br J Dermatol. 1994, 131(1): 23-7.[70]Reichelt J, Doering T, Schnetz E, Fartasch M, Sandhoff K, Magin AM. Normal ultrastructure, but altered stratum corneum lipid and protein composition in a mouse model for epidermolytic hyperkeratosis[J]. J Invest Dermatol. 1999, 113(3): 329-334.[71]Krieg P, Rosenberger S, de Juanes S, et al. Aloxe3 knock-out mice reveal a function of epidermal lipoxygenase -3 ashepoxilin synthase and its pivotal role in barrier formation[J]. J Invest Dermatol, 2013, 133(1):172-180.[72]韩春雨, 韩建文. ALOXE3基因突变致常染色体隐性先天性鱼鳞病一例[J]. 中国麻风皮肤病杂志, 2025, 41(1): 9-14.