<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">CDCST</journal-id><journal-title-group><journal-title>China Daily Chemical Science Technology</journal-title></journal-title-group><issn>2997-7096</issn><eissn>2997-710X</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/CDCST.2025030024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>皮脂代谢的全周期调控机制与干预靶点综述</title><url>https://artdesignp.com/journal/CDCST/2/3/10.61369/CDCST.2025030024</url><author>冯晓月,商建丽,付媛媛,陈勇,刘有停</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>2</volume><issue>3</issue><history><date date-type="pub"><published-time>2025-09-25</published-time></date></history><abstract>皮脂是由皮脂腺分泌的复杂脂质混合物，参与维持皮肤屏障、调节水分、抗菌和缓冲外界刺激。皮脂代谢涉及多层级、多靶点信号通路，调控机制复杂且个体差异明显。本文系统梳理皮脂合成、分泌、降解等生理过程，阐明了皮脂代谢紊乱对皮肤健康的影响，并重点解析了PPAR&amp;gamma;、雄激素信号、SREBP转录因子及脂滴自噬等关键调控环节，同时综述了相应的潜在干预靶点。构建&amp;ldquo;源头&amp;mdash; 前端&amp;mdash; 中端&amp;mdash; 终端&amp;mdash; 末端&amp;rdquo;的全周期调控框架，为精准控油策略及功能性护肤产品研发提供理论依据和实践指导。</abstract><keywords>皮脂代谢,PPARγ,雄激素,SREBP,脂滴自噬,皮脂调控</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Smith KR, Thiboutot DM. Thematic review series: skin lipids.Sebaceous gland lipids: friend or foe? [J]. J Lipid Res, 2008, 49(2): 271.[2]王倩, 刘菲, 杨素珍, 等. 皮脂腺在护肤领域的研究进展[J]. 日用化学工业, 2022, (8): 52.[3]Shamloul G, Khachemoune A. An updated review of the sebaceous gland and its role in health and diseases Part 1: Embryology, evolution,structure, and function of sebaceous glands [J]. Dermatol Ther, 2021,34(1): e14695.[4]Knox S, O&amp;rsquo;Boyle NM. Skin lipids in health and disease: A review [J].Chem Phys Lipids, 2021, 236:105055.[5]Clayton RW, Langan EA, Ansell DM, et al. Neuroendocrinology and neurobiology of sebaceous glands [J]. Biol Rev Camb Philos Soc, 2020,95(3): 592.[6]Sun W, Li P, Cai J, et al. Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus [J]. Front Immunol, 2022, 13: 860586.[7]Xie Y, Li J, Kang R, et al. Interplay Between Lipid Metabolism and Autophagy [J]. Front Cell Dev Biol, 2020, 8: 431.[8]Jarocki M, Turek K, Saczko J, et al. Lipids associated with autophagy: Mechanisms and therapeutic targets [J]. Cell Death Discovery, 2024, 10(1): 460.[9]Shi L, Wang K, Deng Y, et al. Role of lipophagy in the regulation of lipid metabolism and the molecular mechanism [J]. Nan Fang Yi Ke Da Xue Xue Bao. 2019,3 9(7):867.[10]Grabner G F, Xie H, Schweiger M, et al. Lipolysis: cellular mechanisms for lipid mobilization from fat stores [J]. Nat Metab, 2021,3(11): 1445.[11]Zechner R, Madeo F, Kratky D. Cytosolic lipolysis and lipophagy: two sides of the same coin [J]. Nat Rev Mol Cell Bio, 2017, 18(11):671.[12]Cavallo A, Camera E, Bottillo G, et al. Biosignatures of defective sebaceous gland activity in sebum-rich and sebum-poor skin areas in adult atopic dermatitis. Exp Dermatol. 2024;33(3):e15066.[13]Kato, C., Kusumoto, I., Kato, S., Otoki, Y., Ito, J., Totsuka, H., Rajgopal, A., Hong, J., &amp;amp; Nakagawa, K. (2024). Induction of ferroptosis in human keratinocyte HaCaT cells by squalene hydroperoxide: Possible prevention of skin ferroptosis by botanical extracts. Biochemical and biophysical research communications, 698, 149553 .[14]Veniaminova NA, Jia Y, Hartigan AM, et al. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury [J]. Cell Rep, 2023, 42(9): 113121.[15]Zouboulis CC, Coenye T, He L, et al. Sebaceous immunobiologyskin homeostasis, pathophysiology, coordination of innate immunity and inflammatory response and disease associations [J]. Front Immunol, 2022, 13: 1029818.[16]Okoro OE, Camera E, Flori E, et al. Insulin and the sebaceous gland function [J]. Front Physiol, 2023, 14: 1252972.[17]Ottaviani M, Flori E, Mastrofrancesco A, et al. Sebocyte differentiation as a new target for acne therapy: an in vivo experience [J]. J Eur Acad Dermatol Venereol, 2020, 34(8):1803.[18]Wu M, Liu D, Zeng R, et al. Epigallocatechin-3-gallate inhibits adipogenesis through down-regulation of PPAR&amp;gamma; and FAS expression mediated by PI3K-AKT signaling in 3T3-L1 cells [J]. Eur J Pharmacol, 2017, 795: 134.[19]Tollenaere M, Boira C, Chapuis E, et al. Action of Mangifera indica Leaf Extract on Acne-Prone Skin through Sebum Harmonization and Targeting C. acnes [J]. Molecules. 2022, 27(15): 4769.[20]You J, Ji H, Roh KB, et al. Anti-acne effects of Castanea crenata bur extract and identification of active compound [J]. Appl Biol Chem, 2022, 65(1): 12.[21]Del Rosso J Q, Kircik L. The cutaneous effects of androgens and androgen-mediated sebum production and their pathophysiologic and therapeutic importance in acne vulgaris [J]. J Dermatol Treat, 2024, 35(1): 2298878.[22]贾仁川, 林景荣. 雄激素在痤疮发病机制中的作用及治疗应用[J]. 中国皮肤性病学杂志, 2023, 37(5): 503.[23]Crocco E I, Bonif&amp;aacute;cio E B, Facchini G, et al. Modulation of skin androgenesis and sebum production by a dermocosmetic formulation [J]. J Cosmet Dermatol-us, 2021, 20(1): 360.[24]Escamilla-Cruz M, Maga&amp;ntilde;a M, Escand&amp;oacute;n-Perez S, et al. Use of 5-alpha reductase inhibitors in dermatology: a narrative review [J]. Dermatol Ther, 2023, 13(8): 1721.[25]Baltaci AK, Mogulkoc R, Baltaci SB. Review: The role of zinc in the endocrine system [J]. Pak J Pharm Sci, 2019, 32(1): 231.[26]Chakrabarty, Anirban Kr; Banerjee, et al. In vitro 5&amp;alpha;-reductase inhibition by selected Ayurvedic herbs for androgenic disorders [J]. Int J Ayurveda Res, 2024, 5(4): 266.[27]Shimano H, Sato R. SREBP-regulated lipid metabolism: convergent physiology&amp;mdash;divergent pathophysiology [J]. Nat Rev Endocrinol, 2017, 13(12): 710.[28]Wang X, Chen Y, Meng H, et al. SREBPs as the potential target for solving the polypharmacy dilemma [J]. Front Physiol, 2024,14:1272540.[29]Liu X, Hu M, Ye C, et al. Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPAR&amp;alpha; pathway [J]. Chembiol Interact, 2022, 368:110250.[30]Ree J, Kim JI, Lee CW, et al. Quinizarin suppresses the differentiation of adipocytes and lipogenesis in vitro and in vivo viadownregulation of C/EBP-beta/SREBP pathway [J]. Life Sci, 2021, 287:120131.[31]Wu G, Sun X, Cheng H, et al. Large Yellow Tea Extract Ameliorates Metabolic Syndrome by Suppressing Lipogenesis through SIRT6/SREBP1 Pathway and Modulating Microbiota in Leptin ReceptorKnockout Rats [J]. Foods, 2022, 11(11): 1638.[32]Schott M B, Rozeveld C N, Weller S G, et al. Lipophagy at a glance [J]. J Cell Sci, 2022, 135(5): 259402.[33]Zhang S, Peng X, Yang S, et al. The regulation, function, and role of lipophagy, a form of selective autophagy, in metabolic disorders [J].Cell Death Dis, 2022, 13(2): 132.[34]Sabini JH, Timotius KH. Hepatoprotective and Fat-Accumulation-Reductive Effects of Curcumin on Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) [J]. Curr Issues Mol Biol, 2025,47(3): 159.[35]Sikur N, B&amp;ouml;r&amp;ouml;czky C, Pasztern&amp;aacute;k A, et al. Resveratrol and Its Derivatives Diminish Lipid Accumulation in Adipocytes In Vitro-Mechanism of Action and Structure-Activity Relationship [J]. Nutrients, 2024, 16(22): 3869.[36]Wan K, Li J, Ma L, et al. Camellia saponin modulates oleic acid/linoleic acid-induced lipogenesis in human sebocytes through lipophagy activation [J]. Int J Cosmet Sci, 2025, 00: 1.[37] 张艳, 杨依林, 袁家奇, 等. 槲皮素通过上调脂解和脂噬途径改善肝细胞脂质蓄积 [J]. 陆军军医大学学报, 2024, 46(20): 2301.[38] 魏娟. 油性皮肤调控研究进展[J]. Detergent &amp;amp; Cosmetics, 2022,45(10): 50.[39]Zafar K, Lee A, Wang JY, et al. The potential cutaneous benefits of bentonites and montmorillonites [J]. Arch Dermatol Res, 2024, 316:702.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
