<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.12549</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>临床药师参与治疗1例15岁患者确诊囊性纤维化伴铜绿假单胞菌感染的病例分析</title><url>https://artdesignp.com/journal/MRP/3/1/10.61369/MRP.12549</url><author>李雨,吴韶</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>1</issue><history><date date-type="pub"><published-time>2025-01-20</published-time></date></history><abstract>目的：探讨临床药师参与治疗1例15岁患者确诊囊性纤维化伴铜绿假单胞菌感染病例的思路与方法，为临床治疗囊性纤维化伴铜绿假单胞菌感染积累经验以及临床药师药学服务方法。方法：临床药师参与病例讨论及会诊，进行药品不良反应监测，协助医生制定有效治疗方案 。结果：患者确诊性纤维化伴铜绿假单胞菌感染并得到有效治疗，好转出院。结论： 临床药师参与患者囊性纤维化伴铜绿假单胞菌感染会诊，可以协助医师有效提高临床治疗效果，促进患者合理、安全使用抗菌药物。</abstract><keywords>临床药师,囊性纤维化：铜绿假单胞菌感染,会诊,案例分析</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] 郭小贝，田欣伦. 囊性纤维化// 中国第一批罕见病目录释 义［M］.北京: 人民卫生出版社，2018:315-317.[2]Soret P, Vandenborght L E, Francis F, et al. Respiratory mycobiome and suggestion of inter-kingdom network during acute pulmonary exacerbation in cystic fibrosis[J].Scientific reports, 2020, 10(1): 3589.[3] Xu J, Yin Y, Zhang L, et al. Four case reports of Chinese cystic fibrosis patients and literature review[J]. Pediatric Pulmonology, 2017, 52(8): 1020-1028.[4] Stick SM, Foti A, Ware RS, Tiddens H, Clements BS, Armstrong DS, et al. The effect of azithromycin on structural lung disease in infants with cystic fibrosis (COMBATCF): a phase 3, randomised, double-blind, placebo-controlled clinical trial. Lancet Respir Med. 2022;10(8):776-84.[5] Akkerman-Nijland A M, M&amp;ouml;hlmann J E, Akkerman O W, et al. The long-term safety of chronic azithromycin use in adult patients with cystic fibrosis, evaluatingbiomarkers for renal function, hepatic function and electrical properties of the heart[J]. Expert Opinion on Drug Safety, 2021, 20(8): 959-963.[6]中华医学会心血管病学分会心律失常学组,中华心血管病杂志编辑委员会,中国心脏起搏与心电生理杂志编辑委员会. 获得性长 QT 间期综合征的防治建议[ J]. 中华心血管病杂志,2010,38(11):961-969.[7] Proesmans M, Balinska ‐Miskiewicz W, Dupont L, et al. Evaluating the &amp;ldquo;Leeds criteria&amp;rdquo; for Pseudomonas aeruginosa infection in a cystic fibrosis centre[J]. Eur Respir J,2006, 27(5): 937 ‐943.[8]Ratjen F, Moeller A, Mckinney ML, et al. Eradication of early P. Aeruginosa infection in children&amp;lt;7years of age with cystic fibrosis: the early study [J]. J Cyst Fibros,2019, 18(1): 78 ‐85.[9]囊性纤维化诊断与治疗中国专家共识编写组,中国罕见病联盟呼吸病学分会,中国支气管扩张症临床诊治与研究联盟. 囊性纤维化诊断与治疗中国专家共识（2023版）[J]. 中华结核和呼吸杂志,2023,46(4):352-372.[10]Schwarz C，Sutharsan S，Epaud R，et al.Tezacaftor ivacaftor in people with cystic fibrosis who stopped lumacaftor/ivacaftor due to respiratory adverse events［J］.JCyst Fibros，2021，20（2）:228-233.[11] Middleton PG，Mall MA，Drevinek P，et al. Elexacaftortezacaftor-ivacaftor for cystic fibrosis with a single Phe508del Allele［J］.New England J of Med，2019，381（19）:1809-1819.[12]Burgel P R, Munck A, Durieu I, et al. Real-life safety and effectiveness of lumacaftor&amp;ndash;ivacaftor in patients with cystic fibrosis[J]. American Journal of Respiratory andCritical Care Medicine, 2020, 201(2): 188-197.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
