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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025040016</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>miRNA-186-5p在乳腺癌中的研究进展</title><url>https://artdesignp.com/journal/MRP/3/4/10.61369/MRP.2025040016</url><author>罗鹏,杨林,王炳胜</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>4</issue><history><date date-type="pub"><published-time>2025-04-20</published-time></date></history><abstract>&amp;nbsp; &amp;nbsp; 随着对miRNA以及乳腺癌研究深入，人们发现miRNA在乳腺癌的分子分型、发生、发展、治疗等各个方面起到关键作用。MiRNA-186 &amp;nbsp; &amp;nbsp;是一种重要的 &amp;nbsp; &amp;nbsp;miRNA，通过差异性表达，参与各种癌症的细胞增殖、凋亡、迁移和侵袭。但其在乳腺癌中的报道较少，本文就miRNA-186-5p在乳腺癌中的作用做一下总结，并提出一些miRNA-186-5p在乳腺癌中潜在的机制，希望其可能成为乳腺癌预后指标和治疗的靶向目标。</abstract><keywords>乳腺癌,miRNA-186-5p,耐药,免疫,靶向治疗</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>1]Zhihui, J.; Jia, Y.; Sen, C.; Yijun, R.; Weichun, G., CircDOCK1 Regulates miRNA-186/DNMT3A to Promote Osteosarcoma Progression. Biomedicines 2022, 10 (12).&amp;nbsp;[2]Qianjin, Z.; Lin, H.; Zhiyong, S.; Fengye, W.; Conghui, H., MiRNA-186-5p suppresses cell migration, invasion, and epithelial mesenchymal transition in bladder cancer&amp;nbsp;by targeting RAB27A/B. Environ Toxicol 2021, 36 (11).&amp;nbsp;[3]Wang, Z.; &amp;nbsp;Sha, H. H.; Li, H. J., Functions and mechanisms of miRNA-186 in human cancer. Biomed Pharmacother 2019, 119, 109428.&amp;nbsp;[4]X, L.; &amp;nbsp;X, Z.; &amp;nbsp;Y, C.; &amp;nbsp;Y, H.; &amp;nbsp;J, H.; H, L., miRNA-186-5p targeting SIX1 inhibits cisplatin resistance in non-small-cell lung cancer cells (NSCLCs). Neoplasma 2019, 67 (1).&amp;nbsp;[5]Vivien, B.; &amp;nbsp;Xu, Y.; &amp;nbsp;Anne S, B.; &amp;nbsp;Emmanuel, A.; &amp;nbsp;Elke, E.; &amp;nbsp;Johannes, H.; &amp;nbsp;Rainer M, B.; &amp;nbsp;Eckart, M.; &amp;nbsp;Yingjun, Z.; &amp;nbsp;Michael D, M.; &amp;nbsp;Matthias W, L.; Yuan, G., Hypoxia-induced downregulation of microRNA-186-5p in endothelial cells promotes non-small cell lung cancer angiogenesis by upregulating protein kinase C alpha. Mol Ther&amp;nbsp;Nucleic Acids 2023, 31 (0).&amp;nbsp;[6]Liu, Y.; &amp;nbsp;Jiang, Y.; &amp;nbsp;Xu, L.; &amp;nbsp;Qu, C.; &amp;nbsp;Zhang, L.; &amp;nbsp;Xiao, X.; &amp;nbsp;Chen, W.; &amp;nbsp;Li, K.; &amp;nbsp;Liang, Q.; Wu, H., circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miRNA-186-5p/MYH9 Axis in Gastric Cancer. Cancer Manag Res 2020, 12, 5945-5956.&amp;nbsp;[7]Shan, Y.; Li, P., Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiRNA-186-5p/MAP4K3 Axis in Hepatocellular&amp;nbsp;Carcinoma. Yonsei Med J 2019, 60 (9), 842-853.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
