MRPMedical Research and Practice2993-96902993-9704Art and Design10.61369/MRP.2025070006Article胃肠道间质瘤的免疫微环境特征及其治疗进展研究https://artdesignp.com/journal/MRP/3/7/10.61369/MRP.2025070006曹景怡,张晨,荆哲,庄坤2025372025-07-20胃肠间质瘤（gastrointestinal    stromal    tumor,    GIST）是一类源自间叶组织的消化道常见肿瘤，近年来，随着对其发病机制的深入探索，其在肿瘤免疫微环境（tumor    immune    microenvironment,    TIME）中的特征逐渐受到广泛关注。研究发现，GIST的发生与发展密切依赖其特有的免疫微环境构成及调控网络。随着免疫治疗的快速发展，系统解析GIST中免疫微环境的组成、功能及其动态调控机制，已成为提升治疗响应率、推动新型疗法开发的关键方向。本文系统综述了GIST免疫微环境的主要特征及其在肿瘤进展中的作用，分析当前生物治疗的潜力与局限，并结合最新研究进展，提出未来可能的研究与临床转化路径。免疫微环境,胃肠道间质瘤,免疫治疗,靶向治疗

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