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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025080011</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>基于SLS 复合维生素B 配方在额叶皮质发育与专注力维持中的机制研究</title><url>https://artdesignp.com/journal/MRP/3/8/10.61369/MRP.2025080011</url><author>LiJing,JadeCooper,JacobKwok</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>8</issue><history><date date-type="pub"><published-time>2025-08-20</published-time></date></history><abstract>SLS 复合维生素 B 含多种 B 族维生素及甘氨酸锌、酒石酸氢胆碱等成分，通过参与能量代谢、促进神经发育、调节神经递质平衡、减轻氧化应激与炎症，调控额叶皮质功能以支持专注力。临床研究显示，其对 4-12 岁注意力缺陷青少年儿童改善显著，12-16 岁效果有限，可能与生理发育、任务复杂度等相关。本文为后续明确剂量效应关系与分子机制、优化配方以满足不同人群需求，提供了重要参考。</abstract><keywords>复合维生素B,大脑,额叶皮质发育,专注力,功效机制</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Goldman-Rakic, P. S. (1995). Cellular basis of working memory. Neuron, 14(3), 477-485.[2]Gogtay, N. , Giedd, J. N. , Lusk, L. , Hayashi, K. M. , Greenstein, D. , &amp;amp; Vaituzis, A. C. . (2004). Dynamic mapping of human cortical development during childhood through early adulthood. Proceedings of the National Academy of Sciences, 101(21), 8174-8179.[3]Miller, E. K. , &amp;amp; Cohen, J. D. . (2001). An integrative theory of prefrontal cortex function. Annual Review of Neuroscience, 24(1), 167-202.[4]Fuster, J. M. (2008). The Prefrontal Cortex (4th ed.). Academic Press.[5]Ridderinkhof, K. R. , Ullsperger, M. , Crone, E. A. , &amp;amp; Nieuwenhuiss, S. . (2004). The role of the medial frontal cortex in cognitive control. Science, 306(5695), 443-447.[6]Petersen, S. E. , &amp;amp; Posner, M. I. . (2012). The attention system of the human brain: 20 years after. Annual Review of Neuroscience, 35(1), 73-89.[7]Arnsten, A. F. T. , &amp;amp; Rubia, K. . (2012). Neurobiological circuits regulating attention, cognitive control, motivation, and emotion: disruptions in neurodevelopmental psychiatric disorders. J Am Acad Child Adolesc Psychiatry, 51(4), 356-367.[8]Robbins, T. W. , &amp;amp; Arnsten, A. F. T. . (2009). Robbins tw, arnsten aft. the neuropsychopharmacology of fronto-executive function: monoaminergic modulation. annu revneurosci 32: 267-287. Annual Review of Neuroscience, 32(1), 267-287.[9]Block, M. L., and Calder&amp;oacute;n-Garcidue&amp;ntilde;as, L. (2009). Air Pollution: Mechanisms of Neuroinflammation and CNS Disease. Trends Neurosci. 32 (9), 506&amp;ndash;516.[10]Kennedy, D. O. (2016). B Vitamins and the Brain: Mechanisms, Dose and Efficacy&amp;mdash;A Review. Nutrients, 8(2), 68.[11]Smith AD, Refsum H. Homocysteine, B vitamins, and cognitive impairment. Annu Rev Nutr. 2016;36:211&amp;ndash;39.[12]Mikkelsen, Kathleen, Apostolopoulos, Vasso, Prakash, &amp;amp; Monica, et al. (2017). The effects of vitamin b on the immune/cytokine network and their involvement in depression. Maturitas: International Journal for the Study of the Climacteric.[13]Gibson, G. E. , &amp;amp; Blass, J. P. . (2007). Thiamine-dependent processes and treatment strategies in neurodegeneration. Antioxidants &amp;amp; Redox Signaling, 9(10), 1605-19.[14]Bruce N Ames. (2012). Vitamin and mineral inadequacy accelerates aging-associated diseases. General Information.[15]Hansen, R. E. , Roth, D. , &amp;amp; Winther, J. R. . (2009). Hansen re, roth d, winther jr. quantifying the global cellular thiol-disulfide status. proc natl acad sci usa 106: 422-427. Proceedings of the National Academy of Sciences, 106(2), 422-427.[16]Reynolds, E. . (2006). Vitamin b12, folic acid, and the nervous system. Lancet Neurology, 5(11), 949-960.[17]Black, M. M. . (2008). Effects of vitamin b12 and folate deficiency on brain development in children. Food &amp;amp; Nutrition Bulletin, 29(2 Suppl), 126-31.[18]Czeizel, A. , &amp;amp; Dud&amp;Aacute;S, I. . (1993). Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. Obstetrical and gynecological survey.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
