<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025090004</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>儿童髂骨朗格汉斯细胞组织细胞增生症1例报告并文献复习</title><url>https://artdesignp.com/journal/MRP/3/9/10.61369/MRP.2025090004</url><author>王晟,孟涛方,陈晨,邓世康</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>9</issue><history><date date-type="pub"><published-time>2025-09-20</published-time></date></history><abstract>本文报告1例7岁男童左髋臼单发朗格汉斯细胞组织细胞增生症(LCH)。患儿以左大腿疼痛6周就诊，影像学提示左侧髋臼骨质破坏伴周围水肿，初诊考虑嗜酸性肉芽肿。经切开活检确诊LCH后行病灶刮除联合髂骨植骨术。术后症状缓解，随访1年无复发。本文结合文献探讨髂骨LCH的临床特点、诊断要点及治疗策略。</abstract><keywords>髂骨,朗格汉斯细胞,细胞增生症,儿童,病例报告</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Gulati N, Allen CE. Langerhans cell histiocytosis: Version 2021[J]. Hematol Oncol. 2021;39 Suppl 1(Suppl 1):15-23.[2]Bagnasco F, Zimmermann SY, Egeler RM, et al. Langerhans cell histiocytosis and associated malignancies: A retrospective analysis of 270 patients[J]. Eur J Cancer. 2022;172:138-145.[3]Allen CE, Merad M, McClain KL. Langerhans-Cell Histiocytosis[J]. N Engl J Med. 2018;379(9):856-868.[4]de Menthon M, Meignin V, Mahr A, et al.Histiocytose &amp;agrave; cellules de Langerhans de l&amp;rsquo;adulte [Adult Langerhans cell histiocytosis][J]. Presse Med. 2017;46(1):55-69.[5]Galluzzo Mutti L, Picarsic J. Updates on Langerhans cell histiocytosis and other histiocytosis in children: invited review-challenges and novelties in paediatric tumours[J]. Virchows Arch. 2025;486(1):189-204.[6]H&amp;eacute;ritier S, Emile JF, H&amp;eacute;lias-Rodzewicz Z, et al. Progress towards molecular-based management of childhood Langerhans cell histiocytosis[J]. Arch Pediatr. 2019;26(5):301-307.[7]Lian C, Lu Y, Shen S. Langerhans cell histiocytosis in adults: a case report and review of the literature[J]. Oncotarget. 2016;7(14):18678-18683.[8]H&amp;eacute;ritier S, H&amp;eacute;lias-Rodzewicz Z, Chakraborty R, et al. New somatic BRAF splicing mutation in Langerhans cell histiocytosis[J]. Mol Cancer. 2017;16(1):115.[9]Jezierska M, Stefanowicz J, Romanowicz G, Kosiak W, Lange M. Langerhans cell histiocytosis in children - a disease with many faces. Recent advances in pathogenesis, diagnostic examinations and treatment[J]. Postepy Dermatol Alergol. 2018;35(1):6-17.[10]蒋文轩,叶芳华,肖逸心,等.72例朗格汉斯细胞组织细胞增生症患儿临床分析[J].中国当代儿科杂志,2025,27(05):555-562.[11]Wu C, Li K, Hei Y, et al.. MR imaging features of orbital Langerhans cell Histiocytosis[J].BMC Ophthalmol. 2019;19(1):263. Published 2019 Dec 19.[12]毕娅,吴丹丹,余方颖,等.骨朗格汉斯组织细胞增生症八例并文献复习[J].中国医学科学院学报,2025,47(02):325-332.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
