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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025090031</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>胃癌化疗引起的骨髓抑制及其预测模型</title><url>https://artdesignp.com/journal/MRP/3/9/10.61369/MRP.2025090031</url><author>张蔓,黄福杨,骆玉霜</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>9</issue><history><date date-type="pub"><published-time>2025-09-20</published-time></date></history><abstract>骨髓抑制是胃癌化疗过程中常见且严重的副作用之一。建立有效的风险预测模型有助于早期识别高危患者，指导临床干预，并改善治疗预后。本文综述了胃癌化疗后骨髓抑制的主要危险因素，评估了现有预测模型的临床应用效果，并对不同模型的优缺点进行了比较。同时，本文还分析了当前研究中的局限性，并展望了未来的研究方向，旨在为个体化防治策略的制定提供参考依据。</abstract><keywords>胃癌,化疗,骨髓抑制,预测模型</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] Bray F, Laversanne M, Sung H, et al. Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA: a cancer journal for clinicians, 2024, 74(3): 229-263.[2]高鸿超,彭智.晚期胃癌的综合治疗进展[J].中国肿瘤临床,2024,51(17):896-901.[3]秦叔逵,马军.中国临床肿瘤学会（CSCO）肿瘤放化疗相关中性粒细胞减少症规范化管理指南（2021）[J].临床肿瘤学杂志,2021,26(7):638-648.[4]黄新娟,李旭英,谌永毅,等.肿瘤患者化疗后骨髓抑制发生风险预测模型的研究进展[J].肿瘤药学,2024,14(3):327-331.[5]叶勇,翁金森,林艳,等.恶性肿瘤患者化疗后发生骨髓抑制的影响因素[J].医学新知杂志,2019,29(5):560-561.[6]李茁钰,刘凯,张维汉,等.全球及中国胃癌的流行病学特点及趋势:2018&amp;ndash;2022《全球癌症统计报告》解读[J].中国普外基础与临床杂志, 2024, 31(10):1236-1245.[7]袁芳润,王新新.非小细胞肺癌首次化疗患者骨髓抑制发生情况及其危险因素分析[J].反射疗法与康复医学,2024,5(21):117-120.[8] Que W C, Huang Y F, Lin X Y, et al. Paclitaxel, 5-fluorouracil, and leucovorin combination chemotherapy as first-line treatment in patients with advanced gastric cancer[J]. Anti-Cancer Drugs, 2019, 30(3): 302-307.[9] Bian Y, Xie F, Han J, et al. Nutritional evaluation study based on NRS 2002, OPNI, and their combined use in patients with adverse drug reactions after chemotherapy: a cross-sectional study[J]. Annals of Translational Medicine, 2022, 10(4): 180.
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