<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025100041</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>中医药通过脑肠轴调控“肠道菌群-神经炎症-淀粉样蛋白”轴干预阿尔茨海默病的机制研究进展</title><url>https://artdesignp.com/journal/MRP/3/10/10.61369/MRP.2025100041</url><author>孙雨菲,贾镇泽,王艳艳</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>10</issue><history><date date-type="pub"><published-time>2025-10-20</published-time></date></history><abstract>阿尔茨海默病（AD）是一种常见的神经退行性疾病，以淀粉样蛋白（A&amp;beta;）沉积、Tau蛋白异常磷酸化及神经炎症为核心病理特征。近年研究发现，脑肠轴及其介导的&amp;ldquo;肠道菌群-神经炎症-A&amp;beta;&amp;rdquo;轴在AD发生发展中起关键作用。中医药凭借&amp;ldquo;整体调节&amp;rdquo;和&amp;ldquo;多靶点干预&amp;rdquo;的优势，在调控该轴上显示出良好潜力。本文系统综述AD病理机制、脑肠轴作用及中医药通过调节肠道菌群、抑制神经炎症、干预A&amp;beta;代谢等多途径防治AD的机制，为AD的中医药治疗提供理论依据与新策略。</abstract><keywords>阿尔茨海默病,脑肠轴,肠道菌群-神经炎症-淀粉样蛋白轴,中医药干预,多靶点调控</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>&amp;nbsp;[1] 2023 Alzheimer&amp;rsquo;s disease facts and figures[J]. 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