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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025110031</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>胃癌免疫治疗疗效预测的生物标志物研究进展</title><url>https://artdesignp.com/journal/MRP/3/11/10.61369/MRP.2025110031</url><author>魏煜松</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>11</issue><history><date date-type="pub"><published-time>2025-11-20</published-time></date></history><abstract>胃癌是全球常见的消化道恶性肿瘤，免疫检查点抑制剂的应用显著改善了患者预后，但疗效存在个体差异。本综述旨在系统探讨用于评估胃癌免疫治疗应答的生物标志物。除PD-L1、dMMR/MSI、TMB和EBV等已确立的标志物外，本文还对肿瘤免疫微环境、ctDNA及肠道菌群等一系列新兴标志物进行了深入梳理。这些标志物在指导个体化治疗中具有重要价值，未来将趋向多维度整合与动态监测，以提升预测精准度。</abstract><keywords>胃癌,免疫治疗,生物标志物,PD-L1,MSI,TMB,ctDNA</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>&amp;nbsp;[1]Siegel R L, Giaquinto A N, Jemal A. 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