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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.2025120016</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>芦荟大黄素抗肿瘤药理作用及其分子机制研究进展</title><url>https://artdesignp.com/journal/MRP/3/12/10.61369/MRP.2025120016</url><author>刘丹,王婧,张琪,蔡德富,任珊,关爽</author><pub-date pub-type="publication-year"><year>2025</year></pub-date><volume>3</volume><issue>12</issue><history><date date-type="pub"><published-time>2025-12-20</published-time></date></history><abstract>芦荟大黄素（Aloe-emodin，AE）是一种天然蒽醌类化合物，广泛存在于大黄属和芦荟等药用植物中。研究表明，它具有显著的抗肿瘤活性，其作用机制涉及多种信号通路和分子靶点，能够通过抑制肿瘤细胞增殖、诱导凋亡和焦亡、阻碍迁移与侵袭、抑制肿瘤血管生成，以及调控肿瘤微环境等途径发挥抗癌效应。本文基于国内外AE的抗肿瘤研究相关文献，对其抗肿瘤药理作用及分子机制进行归纳分析，以期为AE的进一步研发和应用提供参考。</abstract><keywords>芦荟大黄素,抗肿瘤,药理作用,分子机制</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1]Sung, H., et al., Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin, 2021. 71(3): p.209-249.[2]Huang, Q., et al., Anti-cancer properties of anthraquinones from rhubarb. Med Res Rev, 2007. 27(5): p. 609-30.[3]Chen, H.C., et al., Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. Food Chem Toxicol, 2004. 42(8): p. 1251-7.[4]Wu, Y.Y., et al., Aloe-emodin (AE) nanoparticles suppresses proliferation and induces apoptosis in human lung squamous carcinoma via ROS generation in vitro and in vivo.Biochem Biophys Res Commun, 2017. 490(3): p. 601-607.[5]Lin, H.D., et al., The effect of aloe-emodin-induced photodynamic activity on the apoptosis of human gastric cancer cells: A pilot study. Oncol Lett, 2017. 13(5): p. 3431-3436.[6]Zhu, M., et al., Exploring the mechanism of aloe-emodin in the treatment of liver cancer through network pharmacology and cell experiments. Front Pharmacol, 2023. 14: p. 1238841.[7]Dai, S., et al., Emodin attenuates cardiomyocyte pyroptosis in doxorubicin-induced cardiotoxicity by directly binding to GSDMD. Phytomedicine, 2023. 121: p. 155105.[8]Li, T., et al., Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells. Front Pharmacol, 2022.13: p. 854526.[9]Peng, M., et al., Sensitization of Non-Small Cell Lung Cancer Cells to Gefitinib and Reversal of Epithelial-Mesenchymal Transition by Aloe-Emodin Via PI3K/Akt/TWIS1 Signal Blockage. Front Oncol, 2022. 12: p. 908031.[10]Qi, J., et al., Endothelial cell specific molecule 1 promotes epithelial-mesenchymal transition of cervical cancer via the E-box binding homeobox 1. PLoS One, 2024. 19(7): p.e0304597.[11]Ma, J.W., et al., Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells.Oncotarget, 2016. 7(37): p. 58915-58930.[12]Kim, H.J., et al., Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways. Life Sci, 2022. 300: p. 120495.[13]Jiang, D., et al., Integrated analysis of potential pathways by which aloe-emodin induces the apoptosis of colon cancer cells. Cancer Cell Int, 2021. 21(1): p. 238.[14]Chen, S., et al., Aloe-emodin targets multiple signaling pathways by blocking ubiquitin-mediated degradation of DUSP1 in nasopharyngeal carcinoma cells. Phytother Res, 2023. 37(7): p. 2979-2994.[15]Bhimaneni, S. and A. Kumar, Abscisic acid and aloe-emodin against NS2B-NS3A protease of Japanese encephalitis virus. Environ Sci Pollut Res Int, 2022. 29(6): p. 8759-8766.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
