<?xml version="1.1" encoding="utf-8"?>
<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.6919</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>PROTAC 靶向蛋白降解技术在精准护肤中的应用前景</title><url>https://artdesignp.com/journal/MRP/2/6/10.61369/MRP.6919</url><author>朱佑民,戴钰,田云才,田勇</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>2</volume><issue>6</issue><history><date date-type="pub"><published-time>2024-06-20</published-time></date></history><abstract>PROTAC精准靶向蛋白降解技术可以精准降解靶蛋白，这意味着此技术可以用于降解对皮肤不友好的蛋白，从而实现精准护肤。本文阐述了PROTAC分子的基本组成和作用机制，探讨了PROTAC分子在护肤品领域的巨大应用前景，旨在打破传统护肤技术的瓶颈，开启真正精准护肤的新纪元。</abstract><keywords>PROTAC，靶向蛋白降解，精准护肤</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] Zhu, YM., Dai, Y., Tian, YC., Tian, Y. New peptide PROTAC is triggering a revolution in precise targeted skincare. 2023, Preprint.[2] Chen, S., Zheng, Y., Liang, B., Yin, Y., Yao, J., Wang, Q., Liu, Y. and Neamati N. The application of PROTAC in HDAC. Eur J Med Chem. 2023, 260:115746.[3] Weng G, Cai X, Cao D, Du H, Shen C, Deng Y, He Q, Yang B, Li D, Hou T. PROTAC-DB 2.0: an updated database of PROTACs. Nucleic Acids Res. 2023, 51(D1):D1367-D1372.[4] Han, D., Wang, L., Jiang, S. and Yang, Q. The ubiquitin-proteasome system in breast cancer. Trends Mol Med. 2023, 29(8), 599-621.[5] PROTAC technology: A new drug design for chemical biology with many challenges in drug discovery. Drug Discov Today. 2023, 28(1):103395.[6] Bou Ghanem GO, Koktysh D, Baratta RO, Del Buono BJ, Schlumpf E, Wareham LK, Calkins DJ. Collagen Mimetic Peptides Promote Repair of MMP-1-Damaged Collagen in the Rodent Sclera and Optic Nerve Head. Int J Mol Sci. 2023, 24(23):17031.[7] 庞树朝，陈美玲，张军平．基于AMPK&amp;alpha;/mTOR/p70S6K通路探讨补肾抗衰片类脂联素受体激动剂样作用干预人主动脉平滑肌细胞增殖的机制［J］．中华中医药杂志，2023,38(10):4711-4716.[8] 郑文婕，童坦君，张宗玉．细胞衰老的重要通路：p16~(INK4a)/Rb和p19~(ARF)/p53/p21~(Cip1) 信号途径［J］．生命的化学，2002,(04):314-316.[9] 闫海龙，龚勇珍．氧化应激及p16和p53/p21与细胞衰老关系的研究进展［J］．医学综述，2011,17(05):682-685.[10] 栗瑞斌，王倩，张雷杰，等．负载酪氨酸酶抑制肽的牛奶外泌体抑制酪氨酸酶活性及黑色素生成研究［J］．天津医科大学学报，2022,28(04):348-352+371.[11] 朱翠翠．调节黑色素生成的主要信号通路［J］．日用化学品科学，2023,46(07):61-70.）[12] 唐卓，付丁强，袁奕，等．靶向降解酪氨酸酶的PROTAC及其应用［P］．四川省，2023,CN202111043833.2.[13] 蒋卓育，王宇嘉，张悦，等．IL-6/IL-6R 抑制剂在免疫炎症性皮肤疾病的应用［J］．中国麻风皮肤病杂志，2024,40(02):145-149.[14] Yixi Y ,Yujin Z ,Xun C , et al.Khasianine ameliorates psoriasis-like skin inflammation and represses TNF-&amp;alpha;/NF-&amp;kappa;B axis mediated transactivation of IL-17A and IL-33 in keratinocytes.［J］．Journal of ethnopharmacology,2022,292115124-115124.[15] Tengfei X ,Mingzhong S ,Chuanxiang Z , et al.TRPV1: A promising therapeutic target for skin aging and inflammatory skin diseases［J］．Frontiers in Pharmacolo gy,2023,141037925-1037925.[16] 高晶，杨镭，雷书敏，等．用于精准蛋白降解和癌症治疗的刺激响应型PROTAC进展（英文）［J］．Science Bulletin,2023,68(10):1069-1085.</p><pub-id pub-id-type="doi"/></element-citation></ref></ref-list></back></article>
