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<article xsi:noNamespaceSchemaLocation="http://jats.nlm.nih.gov/publishing/1.1/xsd/JATS-journalpublishing1-mathml3.xsd" dtd-version="1.1" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance"><front><journal-meta><journal-id journal-id-type="publisher-id">MRP</journal-id><journal-title-group><journal-title>Medical Research and Practice</journal-title></journal-title-group><issn>2993-9690</issn><eissn>2993-9704</eissn><publisher><publisher-name>Art and Design</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.61369/MRP.8020</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title>E3泛素蛋白连接酶在妇科肿瘤发病机制中的研究新进展</title><url>https://artdesignp.com/journal/MRP/2/8/10.61369/MRP.8020</url><author>贾梦迪,燕春艳</author><pub-date pub-type="publication-year"><year>2024</year></pub-date><volume>2</volume><issue>8</issue><history><date date-type="pub"><published-time>2024-08-20</published-time></date></history><abstract>E3泛素蛋白连接酶（E3 ubiquitin ligases，E3s）是泛素-蛋白质降解途径中的关键组分，通过特异性识别底物并催化泛素（Ub）的共价连接，调控包括细胞周期、DNA损伤应答和信号转导等多种生物过程。目前，已有多种针对E3泛素蛋白连接酶的小分子抑制剂被开发，用于干预妇科肿瘤的治疗。然而，由于肿瘤发病机制的复杂性，E3泛素蛋白连接酶的作用也呈现出多样性，为了更有效地将E3泛素蛋白连接酶作为药物靶点使用，我们需要更深入地理解其在不同类型的妇科肿瘤中的具体作用机制，以期望为妇科肿瘤患者提供更加精准和有效的治疗方案。</abstract><keywords>E3 泛素蛋白连接酶 ,妇科肿瘤 ,发病机制 ,治疗靶点 ,研究进展</keywords></article-meta></front><body/><back><ref-list><ref id="B1" content-type="article"><label>1</label><element-citation publication-type="journal"><p>[1] Song MS,Pandolfi PP.The HECT family of E3 ubiquitin ligases and PTEN［J］．Semin Cancer Biol, 2022，85:43-51.PMID: 34129913.[2] Konopleva M, Martinelli G, Daver N, et al. 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