MRPMedical Research and Practice2993-96902993-9704Art and Design10.61369/mrp.6115Article艾司氯胺酮对苏醒期躁动和谵妄影响的meta分析https://artdesignp.com/journal/MRP/2/4/10.61369/mrp.6115刘姝然,方芷萱,盖凡铮,王娜2024242024-04-20目的 对艾司氯胺酮对苏醒期躁动和谵妄影响进行meta分析。方 法 检索英文数据库 2023年11月14日前发表的关于艾司氯胺酮应用和苏醒期躁动和谵妄关系的文献，计算效应指标OR值和95%CI。用漏斗图和egger法评估发表偏倚。用TSA9.0进行试验序贯分析。结 果 META分析结果显示接受艾司氯胺酮的患者术后躁动的发生率显著降低（OR = 0.2, 95%CI [0.11; 0.37], I2 = 0%）术后谵妄的发生率显著降低（OR = 0.32, 95% CI [0.71; 0.60], I2 =0%）。且试验序贯分析进一步肯定了meta分析的结果。结论无论剂量、使用的给药模式或手术类型如何，围术期输注艾司氯胺酮可以降低术后躁动和谵妄的发生率。艾司氯胺酮,术后躁动,术后谵妄,Meta,试验序贯分析

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